A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Martin Root Ph.D, Associate Professor (Creator)
Kevin Zwetsloot Ph.D, Associate Professor (Creator)
Institution
Appalachian State University (ASU )
Web Site: http://www.library.appstate.edu/

Abstract: Background: Long chain omega-3 fatty acids from fish oils (O3) are known to have beneficial effects on a number of vascular risk factors in at-risk populations. The effects of a highly bioavailable emulsified preparation on an overweight young adult population are less well known. Methods: Young adults, age 18–30, with body mass indices (BMIs) greater than 23 (average = 28.1) were administered 1.7 g of O3 per day (N = 30) or safflower oil placebo (N = 27) in an emulsified preparation(Coromega, Inc.) for 4 weeks in a double-blind randomized design. Blood was drawn and anthropometric measurements taken before and after dosing. Hemodynamic measures (central pulse wave velocity,augmentation index, and aortic systolic blood pressure), inflammatory cytokines (IL-6, IL-8, IL-10, andtumor necrosis factor-a), red blood cell and plasma phospholipid fatty acid profiles, fasting serum lipids,glucose, and C-reactive protein were measured. Results: Red cell and plasma phospholipid eicosapentaenoic acid and docosahexaenoic acid concentrationsincreased over the four weeks of dosing in the O3 group. Dosing with O3 did not affect central pulse wave velocity, augmentation index, or aortic systolic blood pressure. None of the five American Heart Association metabolic syndrome components improved over the dosing period. None of the inflammatory cytokines, Creactive protein, or lipids (total or LDL cholesterol) improved over the dosing period.Conclusions: No salutary effects of O3 were observed in hemodynamic, metabolic syndrome criteria or inflammatory markers as a result of this relatively short period of administration in this relatively overweight, but healthy young adult cohort

Additional Information

Publication
Martin Root, Scott R Collier, Kevin A Zwetsloot, Katrina L West and Megan C McGinn(2013) A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young healthy population.Nutrition Journal (vol.12, issue 40)
Language: English
Date: 2013
Keywords
, randomized, fish, omega, arterial, inflammation, metabolic, syndrome,

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