| Title | Date | Views | Brief Description |
|---|
| Response Of M2 Macrophages In A Simulated Tumor Microenvironment To Infection With Vesicular Stomatitis Virus |
2018 |
468 |
Vesicular Stomatitis Virus (VSV) is a good candidate for oncolytic therapy due to its ability to induce apoptosis in a number of different types of cells. VSV's effect on macrophages has not been studied in-depth. Here, the effects of infection with ... |
| The Type I Interferon Anti-Viral Pathway Contributes To Macrophage Polarization Following Infection With Oncolytic Vesicular Stomatitis Virus |
2020 |
319 |
Vesicular stomatitis virus (VSV) is a promising oncolytic agent that directly kills cancer cells, but which also modulates immune elements within the tumor microenvironment. Here we were interested in how VSV affects tumor-associated macrophages (TAM... |
| A Review Of Tumor-Associated Macrophage-Targeted Cancer Therapies |
2021 |
202 |
Tumor-associated macrophages, or TAMs, make up a significant component of the tumor microenvironment and contribute to the human immune response to cancer. TAMs can either take a pro-tumorigenic form, promoted by pro-inflammatory cytokines, that faci... |
| Vesicular Stomatitis Virus Suppresses The Phagocytic Capacity Of A Tumor-Promoting Macrophage Population |
2021 |
218 |
Tumor-associated macrophages (TAMs) have been found in high numbers in aggressive breast cancers, where they often stimulate metastasis and suppress anti-tumor immunity. Such TAMs represent the alternatively activated M2 subtype, though they may exis... |
| The Effect Of Moringa Oleifera On The Oncolytic Activity Of Vesicular Stomatitis Virus In Cervical Cancer Cells |
2015 |
3186 |
Traditional treatment methods for cervical cancer are often not cancer-specific and are associated with adverse side effects. Our lab focuses on developing vesicular stomatitis virus (VSV) as an oncolytic agent due to the natural ability of this viru... |
| Oncolytic Vesicular Stomatitis Virus Inhibits Cancer Cell Invasion Processes |
2017 |
758 |
Vesicular stomatitis virus (VSV) is being investigated as an oncolytic agent due to its capacity to kill cancer cells while exhibiting low virulence in vivo. A trigger for cancer metastasis is the formation of structures known as invadopodia, which f... |
| Therapuetic Targeting Of Macrophage Populations By Oncolytic Vesicular Stomatitis Virus |
2017 |
3462 |
The human immune system is dedicated to ridding the body of foreign pathogens. However, in the context of cancer members of the innate and adaptive immune systems, M2 macrophages in particular, contribute to tumor growth and metastasis and are thus a... |
| The Effects Of Cranberry Supplementation On Inflammation And Macrophage Function In Older, Overweight, Or Obese Individuals |
2023 |
198 |
Cranberries show potential as an anti-inflammatory therapeutic due to their high levels of polyphenol compounds. However, evidence on the anti-inflammatory effects of cranberry is from studies of polyphenol fractions at doses higher than those circul... |
| Moderate Malnutrition Increases NK Cell Population And Inflammatory Activation In The Spleen |
2022 |
133 |
Malaria is a parasitic disease caused by organisms of the genus Plasmodium. The most recent world report detailed 241 million cases of Plasmodium infection with 627,000 deaths in 2020. The success of the parasite is tied to its evolving drug resistan... |
| The Effects of Curcumin and Flavokavain B on the Oncolytic Activity of Vesicular Stomatitis Virus |
2013 |
2340 |
A promising cancer treatment modality is the use of oncolytic viruses to kill cancer cells. One virus that is currently being studied as an oncolytic agent is vesicular stomatitis virus (VSV). We are interested in developing the rM51R-M virus, a matr... |
| Modulation Of Breast Tumor Associated Macrophages By Oncolytic Vesicular Stomatitis Virus |
2019 |
578 |
High tumor-associated macrophage (TAM) densities in cancerous breast tissue often correlates with poor clinical outcomes. This can be attributed to the M2 macrophage subtype whose wound-healing and immunosuppressive functions promote cancer cell prol... |