Clinical Biomarkers and Prognosis in Taiwanese Patients with Non-Small Cell Lung Cancer (NSCLC)
- UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
- Yea-Jyh Chen (Creator)
- Institution
- The University of North Carolina Wilmington (UNCW )
- Web Site: http://library.uncw.edu/
Abstract: Lung cancer is the leading cause of cancer death worldwide with poor survival rates. However, the prognostic factors for survival of patients with lung cancer are not well-established. In this study, we examined the impact ofroutine laboratory biomarkers and traditional factors on survival of patients with non-small cell lung cancer (NSCLC).Method: Secondary data analysis was conducted from a retrospective study of 404 patients with newly diagnosed lungcancer in 2005-2007 in Taiwan. There were eight routine laboratory biomarkers and eight traditional factors investigated in the analyses. Cox proportional hazards model was used to assess the hazard ratios for the association betweenrisk factors and patient overall survival. The Kaplan-Meier method was used to compare survival curves for each prognostic indicator. Results: High WBC counts (HR = 1.798, 95%CI: 1.225 - 2.639), low Hgb level (HR = 1.437, 95%CI:1.085 - 1.903), and low serum albumin level (HR = 2.049, 95%CI: 1.376 - 3.052) were significant laboratory prognosticbiomarkers for poor NSCLC survival. Additionally we confirmed the traditional prognostic factors for poor overall survival among NSCLC patients, including older age, comorbidity conditions, advanced cancer stage, and non-surgicaltreatment. Conclusions: This study identified three available laboratory biomarkers, high WBC counts, low Hgb level,and low serum albumin level, to be significant prognostic factors for poorer overall survival in NSCLC patients. Furtherprognostic evaluation studies are warranted to compare different ethnic groups on the prognostic values of these clinicalparameters in NSCLC survival outcomes. These identified prognostic biomarkers should be included in early riskscreening of hospitalized lung cancer patient population.
Clinical Biomarkers and Prognosis in Taiwanese Patients with Non-Small Cell Lung Cancer (NSCLC)
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Created on 11/1/2023
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Additional Information
- Publication
- Y. Li, Y. Chen, L. Chang, M. Hendryx and J. Luo, "Clinical Biomarkers and Prognosis in Taiwanese Patients with Non-Small Cell Lung Cancer (NSCLC)," Journal of Cancer Therapy, Vol. 3 No. 4A, 2012, pp. 412-423. https://doi.org/10.4236/jct.2012.324054
- Language: English
- Date: 2012
- Keywords
- Biochemical markers, cancer, lungs