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Metabolomics

UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
Teresa Emilea Norris (Creator)
Institution
The University of North Carolina Wilmington (UNCW )
Web Site: http://library.uncw.edu/
Advisor
Susan Simmons

Abstract: Metabolomics is the newest of the “-omics” sciences showing great potential in identifying biomarkers for drug discovery. Since Metabolomics is a relatively new science there are a few issues that have not been investigated to a great extent. As advances in this area are being made, there is a need for better analysis methods that provide adequate and trustworthy results. Presented in this research are the issues that cloud the great potential for analyzing a metabolomics data set. One of the biggest issues comes from the missing values of metabolite concentrations due to an assay threshold. Different imputation methods are evaluated, and how these affect feature selection with respect to a disease status. The goal is to provide more research in these areas through exploration of imputation and feature selection methods. Once conclusions are made, there will be a pathway to help further metabolomics research.

Additional Information

Publication
Thesis
A Thesis Submitted to the University of North Carolina at Wilmington in Partial Fulfillment of the Requirement for the Degree of Masters of Science
Language: English
Date: 2009
Keywords
Biological systems, Metabolic profile tests, Metabolites--Analysis, Metabolites--Mathematical models
Subjects
Metabolic profile tests
Metabolites -- Analysis
Metabolites -- Mathematical models
Biological systems