Synthesis of phospholipid analogs

UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
Stefanie Lee Flippin (Creator)
The University of North Carolina Wilmington (UNCW )
Web Site:
Pam Seaton

Abstract: Phospholipids are fundamental components of all biological membranes. They form the lipid bilayer of the membrane, and their structure is a major determinant in the structure and function of cell membranes. Two synthetic pathways to phospholipid analogs are explored in this work. First, a synthetic pathway starting from glycidol to ultraviolet active diacylglycerides (DAGs) that that have sn-1 and sn-2 ester-linked fatty acids and a chromophore at sn-3 was developed. These DAG derivatives could serve as standards to elucidate the structures of natural phospholipid derivatives. Second, a synthetic pathway to a tethered phospholipid analog with a fluorophore anchored between the sn-1 alkyl chains was developed. This type of lipid analog could serve as a probe to study molecular interactions within the membrane.

Additional Information

A Thesis Submitted to the University of North Carolina at Wilmington in Partial Fulfillment Of the Requirements for the Degree of Master of Science
Language: English
Date: 2009
Bilayer lipid membranes--Metabolism, Phospholipids
Bilayer lipid membranes -- Metabolism

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