Synthesis of phospholipid analogs
- UNCW Author/Contributor (non-UNCW co-authors, if there are any, appear on document)
- Stefanie Lee Flippin (Creator)
- Institution
- The University of North Carolina Wilmington (UNCW )
- Web Site: http://library.uncw.edu/
- Advisor
- Pam Seaton
Abstract: Phospholipids are fundamental components of all biological membranes. They
form the lipid bilayer of the membrane, and their structure is a major determinant in the
structure and function of cell membranes. Two synthetic pathways to phospholipid
analogs are explored in this work. First, a synthetic pathway starting from glycidol to
ultraviolet active diacylglycerides (DAGs) that that have sn-1 and sn-2 ester-linked fatty
acids and a chromophore at sn-3 was developed. These DAG derivatives could serve as
standards to elucidate the structures of natural phospholipid derivatives. Second, a
synthetic pathway to a tethered phospholipid analog with a fluorophore anchored
between the sn-1 alkyl chains was developed. This type of lipid analog could serve as a
probe to study molecular interactions within the membrane.
Synthesis of phospholipid analogs
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Created on 1/1/2009
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Additional Information
- Publication
- Thesis
- A Thesis Submitted to the University of North Carolina at Wilmington in Partial Fulfillment Of the Requirements for the Degree of Master of Science
- Language: English
- Date: 2009
- Keywords
- Bilayer lipid membranes--Metabolism, Phospholipids
- Subjects
- Phospholipids
- Bilayer lipid membranes -- Metabolism