Antioxidant capacity of Nitrogen and Sulfur co-doped carbon nanodots
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Zhenquan Jia, Assistant Professor (Creator)
- Jianjun Wei, Associate Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Carbon nanodots (CNDs) have shown potential for antioxidative activity at the cellular level. Here we applied a facile hydrothermal method to prepare fluorescent nitrogen and sulfur (N,S-) codoped CNDs using a-lipoic acid, citric acid, and urea as precursor molecules. This work describes a comprehensive study for exploring their antioxidation activity using UV–vis absorption and electrochemistry measurements of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•), as well as a lucigenin chemiluminescence (lucigenin-CL) assay. The lucigenin-CL assay detects superoxide anion radicals, i.e., reactive oxygen species (ROS) produced through the xanthine/xanthine oxidase (XO) reaction. The electrochemically derived relationship between the unreacted nitrogen-centered DPPH• and CND concentrations agrees with that obtained from UV–vis measurements. A reaction pathway for the ROS antioxidative reaction of N,S-codoped CNDs is proposed. These findings should aid in the development of N,S-codoped CNDs for practical use in biomedical applications. [The original abstract for this article contains (characters/images) that cannot be displayed here. Please click on the link below to read the full abstract and article.]
Antioxidant capacity of Nitrogen and Sulfur co-doped carbon nanodots
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Created on 6/12/2020
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Additional Information
- Publication
- ACS Applied Nano Materials, 2018, 1(6) 2699-2708. DOI: 10.1021/acsanm.8b00404
- Language: English
- Date: 2018
- Keywords
- carbon nanodots, nitrogen and sulfur doping, antioxidation