System.IO.FileNotFoundException: Could not find file 'D:\inetpub\wwwroot\ir\uncp\f\Daniel Middleton.pdf'. File name: 'D:\inetpub\wwwroot\ir\uncp\f\Daniel Middleton.pdf' at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath) at System.IO.FileInfo.get_Length() at ir.Funct.getfilesize(String file) at listing.ItemList(Int32 _mySrchID) Investigating DNA-Protein Binding Dynamics in Yeast Using a Mathematical Model, UNCP NC DOCKS (North Carolina Digital Online Collection of Knowledge and Scholarship)
 

Investigating DNA-Protein Binding Dynamics in Yeast Using a Mathematical Model

UNCP Author/Contributor (non-UNCP co-authors, if there are any, appear on document)
Daniel Middleton (Creator)
Institution
The University of North Carolina at Pembroke (UNCP )
Web Site: http://www.uncp.edu/academics/library
Advisor
Conner I. Sandefur

Abstract: In this project a mathematical model of DNA-protein binding dynamics was developed for an induced system in the GAL network of genes in Saccharomyces cerevisiae. Experimental data gathered by chromatin immunoprecipitation (ChIP) was the basis for our investigations and the resulting model can be observed to roughly approximate the behavior displayed by the experimental data. Furthermore, a parametric sensitivity analysis of the model showed that its behavior was most dependent on the turnover rate of the induced and constitutive proteins.

Investigating DNA-Protein Binding Dynamics in Yeast Using a Mathematical Model
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