Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b), comprising a tricyclic pyrrolizidine alkaloids subclass; and two that were known but to the species: 7-angeloylretronecine (4) and 9-angeloylretronecine (5). All compounds were tested against a human tumor panel for cytotoxicity; no activity was observed (EC50 values > 20 µg/ml).
Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).
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Created on 1/1/2008
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Additional Information
- Publication
- Phytochemistry 69, 2341-2346
- Language: English
- Date: 2008
- Keywords
- Echium glomeratum, Boraginaceae, Pyrrolizidine alkaloids, Petranine, Angeloylretronecine