| Antimicrobial Fungal Endophytes from the Botanical Medicine Goldenseal (Hydrastis canadensis) |
2016 |
1589 |
The potential of fungal endophytes to alter or contribute to plant chemistry and biology has been the topic of a great deal of recent interest. For plants that are used medicinally, it has been proposed that endophytes might play an important role in... |
| Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds |
2016 |
1420 |
[The original abstract for this article contains images that cannot be displayed here. Please click on the link below to read the full abstract and article.] |
| Biochemometrics to identify synergists and additives from botanical medicines: A case study with Hydrastis canadensis (Goldenseal) |
2018 |
1730 |
A critical challenge in the study of botanical natural products is the difficulty of identifying multiple compounds that may contribute additively, synergistically, or antagonistically to biological activity. Herein, it is demonstrated how combining ... |
| Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study |
2017 |
1441 |
A challenge that must be addressed when conducting studies with complex natural products is how to evaluate their complexity and variability. Traditional methods of quantifying a single or a small range of metabolites may not capture the full chemica... |
| Conventional and Accelerated-Solvent Extractions of Green Tea (Camellia sinensis) for Metabolomics-Based Chemometrics |
2017 |
1485 |
Metabolomics has emerged as an important analytical technique for multiple applications. The value of information obtained from metabolomics analysis depends on the degree to which the entire metabolome is present and the reliability of sample treatm... |
| Detection of Adulteration in Hydrastis canadensis (Goldenseal) Dietary Supplements via Untargeted Mass Spectrometry-Based Metabolomics |
2018 |
1663 |
Current estimates report that approximately 25% of U.S. adults use dietary supplements for medicinal purposes. Yet, regulation and transparency within the dietary supplement industry remains a challenge, and economic incentives encourage adulteration... |
| Endolichenic fungi: a new source of rich bioactive secondary metabolites on the horizon |
2017 |
3083 |
Endolichenic fungi are diverse groups of predominantly filamentous fungi that reside asymptomatically in the interior of lichen thalli. Natural products from endolichenic fungi, isolated from a variety of different lichen species, have been attractin... |
| Integration of biochemometrics and molecular networking to identify antimicrobials in Angelica keiskei |
2018 |
1316 |
Botanical medicines have been utilized for centuries. but it remains challenging to identify bioactive constituents from complex botanical extracts. Bioassay-guided fractionation is often biased toward abundant or easily isolatable compounds. To comp... |