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Heather Romine
Lab Manager and Research Specialist
Biology,
UNCP
heather.romine@uncp.edu
910-775-4187
129 Biotechnology Research and Training Ctr
Pembroke NC 28372
There are 3 included publications by Heather Romine :
Title
Date
Views
Brief Description
Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon
2017
1611
The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in the brain. In rat hippocampal slice cultures, high-dose Pxn was applied resulting in a pre...
Interaction between Proteasomal and Lysosomal Systems Can Be Modulated to Reduce Aß42 Effects in Hippocampal Slice Cultures
2017
634
Intracellular protein clearance decreases with age, thus altering the vital balance between protein synthesis vs. degradation. Accumulating toxic proteins lead to the activation of proteasomal and lysosomal pathways for clearing such species. However...
Potential Alzheimer’s Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain
2017
1392
Cysteine protease inhibitors have long been part of drug discovery programs for Alzheimer's disease (AD), traumatic brain injury (TBI), and other disorders. Select inhibitors reduce accumulating proteins and AD pathology in mouse models. One such com...