Heather Romine

  • Lab Manager and Research Specialist
  • Biology, UNCP
  • heather.romine@uncp.edu
  • 910-775-4187
  • 129 Biotechnology Research and Training Ctr
  • Pembroke NC 28372

There are 3 included publications by Heather Romine :

TitleDateViewsBrief Description
Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon 2017 894 The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in the brain. In rat hippocampal slice cultures, high-dose Pxn was applied resulting in a pre...
Interaction between Proteasomal and Lysosomal Systems Can Be Modulated to Reduce Aß42 Effects in Hippocampal Slice Cultures 2017 522 Intracellular protein clearance decreases with age, thus altering the vital balance between protein synthesis vs. degradation. Accumulating toxic proteins lead to the activation of proteasomal and lysosomal pathways for clearing such species. However...
Potential Alzheimer’s Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain 2017 721 Cysteine protease inhibitors have long been part of drug discovery programs for Alzheimer's disease (AD), traumatic brain injury (TBI), and other disorders. Select inhibitors reduce accumulating proteins and AD pathology in mouse models. One such com...