Thielavin B Methyl Ester: A Cytotoxic Benzoate Trimer from an Unidentified Fungus (MSX 55526) from the Order Sordariales

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Nicholas Oberlies, Patricia A. Sullivan Distinguished Professor of Chemistry (Creator)
Cedric J Pearce, Adjunct Professor (Creator)
Mansukhlal Chhaganlal Wani (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5a,8a-epidioxyergosta-6,9(11),22-trien-3ß-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines.

Additional Information

Tetrahedron Letters, 52(44): 5733-5735. doi: 10.1016/j.tetlet.2011.08.125
Language: English
Date: 2011
Fungi, Cytotoxicity, Benzoate, Thielavin, APPI

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