Symptom trajectories during chemotherapy in outpatients with lung cancer colorectal cancer, or lymphoma.
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- William N. Dudley, Professor Public Health Education (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Purpose
Pain, depression, distress, fatigue, and sleep disturbance are common symptoms in oncology patients, but little data are available that examine the trajectories of these symptoms during chemotherapy (CTX). The purposes of this study were to examine the trajectories of these symptoms during the first six cycles of CTX and to determine whether individual characteristics predicted the trajectories of these symptoms.
Methods
Oncology outpatients (n = 118) with newly diagnosed lung cancer, colorectal cancer, or lymphoma rated symptoms using an electronic patient care monitor system. Pain, fatigue, and sleep disturbance were rated on 0–10 numeric rating scales; depression and distress were evaluated using scales converted to normalized T scores. Latent growth curve analyses (LGCA) examined for intra- and inter-individual differences in the trajectories of these five symptoms during the six cycles of CTX.
Results
Symptoms were present at the initiation of CTX (p < 0.0001) for all symptoms (p < 0.05). Distress (p = 0.03) and pain (p = 0.02) intensity decreased significantly over the six cycles of CTX. Advanced disease and a higher number of comorbidities predicted higher fatigue at baseline (p = 0.02 and 0.01 respectively). A diagnosis of lung cancer predicted an increasing intensity of fatigue during CTX (p = 0.04). Concurrent radiation therapy predicted more intense pain over time (p = 0.03).
Conclusions
While symptom trajectories were highly variable in patients undergoing initial CTX, the majority of the symptom intensity scores decreased over time. However, patients with lung cancer, those with a higher number of comorbidities, and those with advanced disease experienced more intense fatigue and sleep disturbance over time.
Symptom trajectories during chemotherapy in outpatients with lung cancer colorectal cancer, or lymphoma.
PDF (Portable Document Format)
242 KB
Created on 4/17/2013
Views: 1996
Additional Information
- Publication
- Language: English
- Date: 2011
- Keywords
- chemotherapy, oncology, chemotherapy side effects, lung cancer, colorectal cancer, lymphoma, outpatient chemotherapy treatment