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A new hybrid mouse model for agenesis of the corpus callosum

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Douglas Wahlsten, Visiting Professor (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: A three locus model of the inheritance of absent corpus callosum in mice was tested by creating F1 and F2 hybrid crosses from the strains BALB/cWahl and 129/J which show incomplete penetrance for callosal agenesis. The model predicted that a few or the F2 hybrid mice would suffer severe reduction of the hippocampal commissure when the corpus callosum was absent, a condition that usually occurs only in the most consistently acallosal I/LnJ strain, and this prediction was confirmed. The C129F2 hybrid population expresses substantial genetic variation and an extremely wide range of defects of the corpus callosum, dorsal commissure of the fornix and hippocampal commissure. At the same time, these hybrids have exceptionally good health and reproductive performance, unlike their inbred parent strains. These characteristics make them ideal subjects for the study of brain—behaviour correlation using a noninvasive method.

Additional Information

Publication
Behavioral Brain Research, 1994, 64, 111-117.
Language: English
Date: 1994
Keywords
Inbred strain, Incomplete penetrance, Hippocampal commissure, Allometry, Brain—behaviour correlation, Split brain, Genetic analysis, Polygenic