Interaction of CD38 variant and chronic interpersonal stress is associated with social anxiety and depression symptoms over six years
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Suzanne Vrshek-Schallhorn, Associate Professor and Undergraduate Program Director (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: Variation in the CD38 gene, which regulates secretion of the neuropeptide oxytocin, has been associated with several social phenotypes. Specifically, rs3796863 A allele carriers have demonstrated increased social sensitivity. In 400 older adolescents, we used trait-state-occasion modeling to investigate how rs3796863 genotype, baseline ratings of chronic interpersonal stress, and their gene–environment (G×E) interaction predicted trait social anxiety and depression symptoms over 6 years. We found significant G×E effects for CD38 A-carrier genotypes and chronic interpersonal stress at baseline predicting greater social anxiety and depression symptoms. A significant G×E effect of smaller magnitude was also found for C/C genotype and chronic interpersonal stress predicting greater depression; however, this effect was small compared with the main effect of chronic interpersonal stress. Thus, in the context of chronic interpersonal stress, heightened social sensitivity associated with the rs3796863 A allele may prospectively predict risk for social anxiety and (to a lesser extent) depression.
Interaction of CD38 variant and chronic interpersonal stress is associated with social anxiety and depression symptoms over six years
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Created on 8/1/2023
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Additional Information
- Publication
- Clinical Psychological Science 4(1)
- Language: English
- Date: 2015
- Keywords
- CD38, social anxiety, depression, trait-state-occasion modeling, interpersonal stress, gene-environment interaction, oxytocin