a-Klotho Expression in Mouse Tissues Following Acute Exhaustive Exercise

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Yu Feng (Creator)

Hu Huang (Creator)

Zhijian Rao (Creator)

Rengfei Shi (Creator)

Lifang Zheng (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: a-Klotho, a multifunctional protein, has been demonstrated to protect tissues from\r\ninjury via anti-oxidation and anti-inflammatory effects. The expression of a-klotho is\r\nregulated by several physiological and pathological factors, including acute inflammatory\r\nstress, oxidative stress, hypertension, and chronic renal failure. Exhaustive exercise has\r\nbeen reported to result in tissue damage, which is induced by inflammation, oxidative\r\nstress, and energy metabolism disturbance. However, little is known about the effects\r\nof exhaustive exercise on the expression of a-klotho in various tissues. To determine the\r\neffects, the treadmill exhaustion test in mice was performed and the mice were sacrificed\r\nat different time points following exhaustive exercise. Our results confirmed that the\r\nfull-length (130 kDa) and shorter-form (65 kDa) a-klotho were primarily expressed in\r\nthe kidneys. Moreover, we found that, except for the kidneys and brain, other tissues\r\nprimarily expressed the shorter-form a-klotho, including liver, which was in contrast to\r\nprevious reports. Furthermore, the shorter-form a-klotho was decreased immediately\r\nfollowing the acute exhaustive exercise and was then restored to the pre-exercise level\r\nor even higher levels in the next few days. Our results indicate that a-klotho may play a\r\nkey role in the body exhaustion and recovery following exhaustive exercise.

Additional Information

Publication

Other

Language: English

Date: 2023

Subjects

exhaustive exercise, a-klotho, skeletal muscle, liver, adipose tissue

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