Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Abdel A. Abdel-Rahman (Creator)

Mahmoud M. El-Mas (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses\r\nelicited by a2-adrenergic (a-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in\r\ntelemetered female rats.\r\nMain methods—The effects of a-methyldopa or rilmenidine on blood pressure (BP), heart rate\r\n(HR) and their variability were investigated in rats that received liquid diet without or with ethanol\r\n(5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP\r\nand HR variability) in the absence or presence of ethanol, three time-domain indices of hemodynamic\r\nvariability were measured: (i) standard deviation of mean arterial pressure (SDMAP), (ii) standard\r\ndeviation of beat-to-beat intervals, and (iii) root mean square of successive differences in R-R\r\nintervals.\r\nKey findings—In liquid diet-fed control rats, i.p. rilmenidine (600 µg/kg) or a-methyldopa (100\r\nmg/kg) reduced BP along with decreases and increases, respectively, in HR. Both drugs had no effect\r\non HR variability but reduced BP variability (SDMAP), suggesting a reduced vasomotor sympathetic\r\ntone. Ethanol feeding attenuated reductions in BP and SDMAP evoked by a-methyldopa but not by\r\nrilmenidine.\r\nSignificance—We conclude that chronic ethanol preferentially compromises a2- but not I1-\r\nreceptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic\r\nactivity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive\r\nalcoholic females.

Additional Information

Publication

Other

Life Sciences\; 84:3-4 p. 111-118

Language: English

Date: 2023

Subjects

Ethanol;Rilmenidine;Alpha-methyldopa;Hypotension;Females;Rats

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