AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Agne A Shields (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: Loss of a nucleic acid base from DNA can leave behind a reactive aldehyde group on ribose. To detect the presence of such “abasic sites,” ethyl-2-aminoazulene-1-carboxylate, a novel azulene-based analog of guanine/adenine, was synthesized. Valeraldehyde was chosen as a simple model for an abasic site. 1H NMR kinetics studies with ethyl-2-aminoazulene-1-carboxylate and valeraldehyde show that this is a slow reaction and suggest that it is zero-order with respect to valeraldehyde. This is consistent with a complex mechanism.
Additional Information
- Publication
- Thesis
- Language: English
- Date: 2023
- Subjects
- azulene;kinetics;DNA damage
| Title | Location & Link | Type of Relationship |
| AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION | http://hdl.handle.net/10342/12366 | The described resource references, cites, or otherwise points to the related resource. |