Changes in Vascular and Hemodynamic Parameters Following Acute Exercise and Antioxidant Supplementation
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Rebecca Marie Kappus Ph.D, Assistant Professor (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
- Advisor
- Scott Collier
Abstract: Objective: The objective of this study was to investigate the potential additive effects
of the multi-flavonoid plus fish oil combination and aerobic exercise on post exercise
hypotension (PEH). We hypothesize that the use of a multi-flavonoid plus fish oil
supplement in combination with aerobic exercise will show an additive effect on favorable
blood pressure (BP) and pulse wave velocity (PWV) changes while increasing arterial
distensibility. Design: Hemodynamic and vascular measurements were performed pre and
post exercise and before and after double blinded placebo or supplementation of 1000 mg
quercetin (Q) with 120 mg epigallocatechin 3-gallate (EGCG), 400 mg isoquercetin, and 400
mg omega-3 fatty acids from fish oil (Q-EGCG). Setting: Visits took place at the Vascular
Biology and Autonomic Studies lab or the Human Performance lab at Appalachian State
University. Participants: 20 young, healthy, pre-hypertensive subjects not on any
medication, including aspirin or birth control, and without known cardiovascular disease,
diabetes, or hypertension were recruited. Interventions: Two weeks of Q-EGCG or placebo.
Main Outcomes: The dependent variables in this study were PWV, BP, Pulse wave analysis
(PWA), Augmentation index (Alx) and ORAC and FRAP levels. Results: No significant differences were found in PWV (central or peripheral), resting systolic blood pressure (SBP),
diastolic blood pressure (DBP) or ORAC. There were significant differences found in Alx,
FRAP and BP from pre to post supplementation in the post exercise SBP measurements.
Conclusions: Two weeks of supplementation on Q-EGCG produced significant decreases in
Alx, post exercise SBP and an increase in FRAP.
Changes in Vascular and Hemodynamic Parameters Following Acute Exercise and Antioxidant Supplementation
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Created on 8/31/2010
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Additional Information
- Publication
- Thesis
- Kappus, R.M. (2010). Changes in Vascular and Hemodynamic Parameters Following Acute Exercise and Antioxidant Supplementation. Unpublished master’s thesis. Appalachian State University, Boone, NC.
- Language: English
- Date: 2010