The long-term impact of COVID-19 : unveiling the relationship between cognition and quality of life
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Brooke E. Holt (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Kristine Lundgren
Abstract: The purpose of this study was to determine the relationship between a number of factors including cognitive performance and quality of life (QOL), premorbid Verbal IQ and QOL, cognitive performance and premorbid Verbal IQ, and length of time since COVID-19 diagnosis and QOL. In addition, to evaluate whether cognitive performance and premorbid Verbal IQ predict QOL based on perception of cognitive function or one’s well-being in a group of non-hospitalized individuals at least 12 weeks post COVID-19 diagnosis. Twenty-three participants completed the remote study protocol procedures. The protocol consisted of the following tasks: 1. a participant intake form, 2. the Immediate Post Concussion Assessment and Cognitive Testing (ImPACT) Version 4, 3. the Lexical Orthographic Familiarity Test (LOFT), 4. a QOL measure based on emotional health (Neuro-QOL Item Bank v1.0: Positive Affect and Well-Being), and one based on cognitive health (Neuro-QOL Item Bank v2.0: Cognitive Function). The main outcome variables included: the ImPACT Two-Factor Memory and Speed Composites, the LOFT raw score, and T-scores from each QOL measure. A multiple linear regression was used to determine the effect of the Speed Composite from the ImPACT and the LOFT raw score on outcomes from each measure of QOL. A multiple linear regression was also used to determine the effect of the Memory Composite from the ImPACT and the LOFT raw score on outcomes from each measure of QOL. Pearson’s correlations were used to determine the relationship between the following: each QOL measure and both the Memory Composite and Speed Composite from the ImPACT, each QOL measure and the LOFT raw score, the LOFT raw score and both the Memory Composite and Speed Composite from the ImPACT, and each QOL measure and days since COVID-19 diagnosis. Findings revealed small-medium positive relationships between cognition and QOL, a small positive relationship with QOL in the cognitive domain and premorbid Verbal IQ, a small positive relationship between premorbid Verbal IQ and objective memory performance, and a small negative relationship between QOL in the emotional domain and length of time since COVID-19 diagnosis. A majority of the relationships lacked statistical significance. Premorbid Verbal IQ and cognitive performance measured via Speed Composite scores, with outliers included in analysis, predicted QOL in the cognitive domain. No additional predictor models for QOL reached significance. Results must be interpreted with caution given the small sample size (n = 23). Relationships between outcome variables varied based on the QOL measure used and the cognitive area assessed. Given findings, clinicians are encouraged to include a measure of speed performance (i.e., reaction time) when assessing cognitive function in individuals following COVID-19 despite hospitalization status. In addition, providing QOL measures to patients presenting with cognitive deficits may reveal functional impairments. Additional research is needed to better understand the long-term impact of COVID-19 on cognition and QOL.
The long-term impact of COVID-19 : unveiling the relationship between cognition and quality of life
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Created on 12/1/2022
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Additional Information
- Publication
- Dissertation
- Language: English
- Date: 2022
- Keywords
- Coronavirus, COVID-19, QOL, Quality of Life
- Subjects
- COVID-19 (Disease)
- Quality of life
- Cognition