The ligand dependent luminescent properties of a lanthanide-based complex to study and optimize its use as a biomedical label
- WCU Author/Contributor (non-WCU co-authors, if there are any, appear on document)
- Sarah Marie Ryder (Creator)
- Institution
- Western Carolina University (WCU )
- Web Site: http://library.wcu.edu/
- Advisor
- Brian Dinkelmeyer
Abstract: The synthesis of novel electron donating and water-soluble ligands for Eu3+ coordination in efforts to optimize the luminescent properties of a europium TTA complex. Biomedical labeling with luminescent lanthanide complexes can be used to image and measure structural characteristics of proteins and other biological molecules with high spectral purity. This works aims to study structural variations of a PIP ligand that optimize the efficacy of a europium complex for its use as a fluorescent biomedical label. Each PIP ligand was synthesized from 1,10-Phenanthroline-5,6-dione and an aldehyde substituent to be further reacted with Eu(TTA)3.2H2O to form the chelated europium complex. The structure of each PIP ligand was characterized using FT-IR, 1 H NMR, and 13C NMR spectroscopy.
The ligand dependent luminescent properties of a lanthanide-based complex to study and optimize its use as a biomedical label
PDF (Portable Document Format)
3685 KB
Created on 7/1/2021
Views: 226
Additional Information
- Publication
- Thesis
- Language: English
- Date: 2021
- Keywords
- antenna effect, biomedical labeling, fluorescence label, lanthanide luminescence, photoluminescence, synthesis
- Subjects
- Biomedical engineering -- Labels
- Fluorescence
- Rare earth metals -- Luminescence
- Photoluminescence
- Biosynthesis