Hypoxia and panchromatic photosensitizers for photodynamic therapy and photochemotherapy

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
John A. Roque III (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
Sherri McFarland

Abstract: Towards efficient and translational medical research, our group develops disease-specific treatments for targeting certain aspects of cancer therapy using a prodrug light-activated platform, metal polypyridyl complexes for photodynamic therapy (PDT) and photochemotherapy (PCT). In all cases, we accomplish this through a tumor-centered approach coupled with a photophysical model (built on decades of polypyridyl research) to elicit desired reactivity for a given application. In the following body of work, we have compiled several manuscripts and supplementary material as they relate to two key challenges within our fields, namely, overcoming tumor hypoxia and near-infrared applications. Additional emphasis is placed on the screening aspect of this drug discovery and discussed in the “Kitchen Sink” chapter.

Additional Information

Language: English
Date: 2021
Hypoxia anticancer, Near infrared NIR, Osmium Os(II), Photochemotherapy PCT, Photodynamic therapy PDT, Ruthenium Ru(II)
Cancer $x Photochemotherapy
Photosensitization, Biological

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