Cardiovascular disease-related miRNAs expression: potential role as biomarkers and effects of training exercise

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Simona,Zauli,Giorgio,Martelli,Alberto M.,Vitale,Marco,McCubrey,James A.,Capitani,Silvano Ultimo (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Cardiovascular diseases (CVDs) are one of the most important causes of mortalityworldwide, therefore the need of effective preventive strategies is imperative. Agingis associated with significant changes in both cardiovascular structure and functionthat lower the threshold for clinical signs and symptoms, making older people moresusceptible to CVDs morbidity and mortality.microRNAs (miRNAs) modulate gene expression at post-transcriptional level andincreasing evidence has shown that miRNAs are involved in cardiovascular physiologyand in the pathogenesis of CVDs.Physical activity is recommended by the medical community and the cardiovascularbenefits of exercise are multifactorial and include important systemic effects onskeletal muscle, the peripheral vasculature, metabolism, and neuroendocrine systems,as well as beneficial modifications within the myocardium itself.In this review we describe the role of miRNAs and their dysregulation in severaltypes of CVDs. We provide an overview of miRNAs in CVDs and of the effects ofphysical activity on miRNA regulation involved in both cardiovascular pathologiesand age-related cardiovascular changes and diseases.Circulating miRNAs in response to acute and chronic sport exercise appear tobe modulated following training exercise, and may furthermore serve as potentialbiomarkers for CVDs and different age-related CVDs.

Additional Information

Publication

Other

Language: English

Date: 2018

Email this document to