Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Julie L.,Virag,Jitka Horton (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: Myocardial tissue damage that occurs during an ischemic event leads to a spiralingdeterioration of cardiac muscle structural and functional integrity. Reperfusion is the only knownefficacious strategy and is the most commonly used treatment to reduce injury and preventremodeling. However, timing is critical, and the procedure is not always feasible for a varietyof reasons. The complex molecular basis for cardioprotection has been studied for decades butformulation of a viable therapeutic that can significantly attenuate myocardial injury remains elusive.In this review, we address barriers to the development of a fruitful approach that will substantiallyimprove the prognosis of those suffering from this widespread and largely unmitigated disease.Furthermore, we proffer that ephrinA1, a candidate molecule that satisfies many of the importantcriteria discussed, possesses robust potential to overcome these hurdles and thus offers protectionthat surpasses the limitations currently observed.
Additional Information
- Publication
- Other
- Language: English
- Date: 2019
- Keywords
- myocardial infarction; cardioprotection; therapeutic strategies; ephrinA1; ischemia; reperfusion
| Title | Location & Link | Type of Relationship |
| Use of Multifactorial Treatments to Address the Challenge of Translating Experimental Myocardial Infarct Reduction Strategies | http://hdl.handle.net/10342/8347 | The described resource references, cites, or otherwise points to the related resource. |