Substrate utilization during submaximal exercise in children with a severely obese parent

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Audrey D,Colon,Ashley,DuBose,Katrina D,Collier,David,Houm Eaves (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: BackgroundWe have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI-‰â‰¥-‰40-‰kg/m2) individuals; this defect is retained in cell culture suggesting an inherent component. The purpose of the current study was to determine if an impairment in whole-body fatty acid oxidation (FAO) was also evident in children with a severely obese parent.MethodsSubstrate utilization during submaximal exercise (cycle ergometer) was determined in children ages 8--12 y with a severely obese parent (OP, n-‰=-‰13) or two lean/non-obese (BMI range of 18 to 28-‰kg/m2) parents (LP, n-‰=-‰13). A subgroup of subjects (n-‰=-‰3/group) performed 4-‰weeks of exercise training with substrate utilization measured after the intervention.ResultsThe children did not differ in age (LP vs. OP, respectively) (10.7-‰Â±-‰0.5 vs. 10.2-‰Â±-‰0.5 y), BMI percentile (65.3-‰Â±-‰5.2 vs. 75.9-‰Â±-‰7), Tanner Stage (1.4-‰Â±-‰0.2 vs. 1.5-‰Â±-‰0.2), VO2peak (40.3-‰Â±-‰2.7 vs. 35.6-‰Â±-‰2.6-‰ml/kg/min) or physical activity levels (accelerometer). At the same absolute workload of 15-‰W (~38% VO2peak), RER was significantly (P-‰â‰¤-‰0.05) lower in LP vs. OP (0.83-‰Â±-‰0.02 vs. 0.87-‰Â±-‰0.01) which was reflected in a reduced reliance on FAO for energy production in the OP group (58.6-‰Â±-‰5.1 vs. 43.1-‰Â±-‰4.0% of energy needs during exercise from FAO). At a higher exercise intensity (~65% VO2peak) there were no differences in substrate utilization between LP and OP. After exercise training RER tended to decrease (P-‰=-‰0.06) at the 15-‰W workload, suggesting an increased reliance on FAO regardless of group.ConclusionsThese findings suggest that the decrement in FAO with severe obesity has an inherent component that may be overcome with exercise training.

Additional Information

Publication

Other

Language: English

Date: 2012

Keywords

Bariatric surgery, Class III obesity, Exercise, Fat oxidation, Skeletal muscle

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