Is there a metabolic program in the skeletal muscle of obese individuals?
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Joseph A.,Pories,Walter J.,Dohm,G. Lynis Houmard (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: Severe obesity (BMI ≥ 40-‰kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are retained in human skeletal muscle cells raised in culture. Together, these findings are indicative of a dysfunctional global metabolic program with severe obesity which is of an epigenetic or genetic origin. Weight loss via gastric bypass surgery can "turn off" and/or correct components of this metabolic program as insulin sensitivity is restored; however, the impairment in FAO in skeletal muscle remains evident. Physical activity can improve FAO and insulin action, indicating that this patient population is not exercise resistant and that exercise offers a pathway to circumvent the abnormal program. Findings presented in this review will hopefully increase the understanding of and aid in preventing and/or treating the severely obese condition.
Additional Information
- Publication
- Other
- Language: English
- Date: 2011
| Title | Location & Link | Type of Relationship |
| Is there a metabolic program in the skeletal muscle of obese individuals? | http://hdl.handle.net/10342/7745 | The described resource references, cites, or otherwise points to the related resource. |