Magnetoreception of photoactivated cryptochrome 1 in electrochemistry and electron transfer

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Taylor Levi Mabe (Creator)
Jianjun Wei, Associate Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Cryptochromes are flavoproteins whose photochemistry is important for crucial functions associated with phototropism and circadian clocks. In this report, we, for the first time, observed a magnetic response of the cryptochrome 1 (CRY1) immobilized at a gold electrode with illumination of blue light. These results present the magnetic field-enhanced photoinduced electron transfer of CRY1 to the electrode by voltammetry, exhibiting magnetic responsive rate constant and electrical current changes. A mechanism of the electron transfer, which involves photoinduced radicals in the CRY, is sensitive to the weak magnetic field; and the long-lived free radical FAD•– is responsible for the detected electrochemical Faradaic current. As a photoreceptor, the finding of a 5.7% rate constant change in electron transfer corresponding to a 50 µT magnetic field may be meaningful in regulation of magnetic field signaling and circadian clock function under an electromagnetic field. [The original abstract for this article contains (characters/images) that cannot be displayed here. Please click on the link below to read the full abstract and article.]

Additional Information

ACS Omega, 2018, 3 (5), 4752-4759, DOI: 10.1021/acsomega.8b00645
Language: English
Date: 2018
cryptochrome 1 (CRY1), magnetic response, tryptophan

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