Synthesis of PADK Derivatives for the Treatment of Alzheimer's Disease

UNCP Author/Contributor (non-UNCP co-authors, if there are any, appear on document)
Robert W. Lamb (Creator)
The University of North Carolina at Pembroke (UNCP )
Web Site:
Cornelia Tirla

Abstract: Alzheimer's disease is a progressive neurodegenerative disease that slowly destroys memory, thinking capacity, body function, and eventually leads to death. No cure is currently known for this disease and the best medications only slow its inevitable progression. The most prominent theories about the root cause of the disease are the accumulation of either B-amyloid or tau protein plaques. Research is currently underway to develop methods of reducing plaque buildup and hopefully reversing the disease. Previous research endeavors have shown that derivatives of the lysosomal modulator Phe-Ala-Diazomethylketone (PADK) can confer some level of protection against typical Alzheimer's protein accumulation pathology in transgenic mice. Through this research endeavor we have synthesized derivatives of PADK that will be tested for biological activity after confirming that they are structurally different than previously synthesized compounds.

Additional Information

Honors Project
Language: English
Date: 2014
Alzheimer's disease, Neurodegenerative disease, B-Amyloid, Tau Protein Plaques, Lysosomal Modulator, Phe-Ala-Diazomethylketone,

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