Effects of General Anesthetics on Cytochrome C Oxidase

UNCP Author/Contributor (non-UNCP co-authors, if there are any, appear on document)
Leslie Lowry (Creator)
The University of North Carolina at Pembroke (UNCP )
Web Site: http://www.uncp.edu/academics/library
Paul Flowers

Abstract: Studies were conducted to determine the effects of n-alcohols as general anesthetic on the enzyme, cytochrome c oxidase. Results from these studies indicate the following: n-alcohols inhibit the activity of cytochrome c oxidase through hydrophobic interactions; the inhibition of cytochrome c oxidase by a 1:2 n-butanol/buffer mixture is reversible; the amount required for a 50% inhibition of cytochrome c oxidase by n-butanol is 10 times greater than that of physiological concentrations; and n-butanol decreases the rate of reduction of cytochrome c oxidase by NADH/PHS, but does not affect the UV-VIS spectra or the ligand binding rates.

Additional Information

Language: English
Date: 1994

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