Influence Of Vitamin C Supplementation On Oxidative And Salivary IgA Changes Following An Ultramarathon
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Dr.. David Nieman, Director (Creator)
- Steven McAnulty PhD, Professor (Contributor)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
Abstract: This randomized study measured the influence of vitamin C (N=15) compared to placebo (N=13) supplementation on oxidative and salivary immunoglobulin A (sIgA) changes in runners competing in an ultramarathon race. Seven days prior to the race, subjects ingested in randomized, double-blind fashion three 500-mg tablets of vitamin C or placebo each day. On race day, blood and saliva samples were collected 1 h pre-race, after 32 km of running, and then again immediately post-race. During the race, runners received 1 l/h carbohydrate beverages (60 g/l) with vitamin C (150 mg/l) or without in a double-blinded fashion. The runners also ingested two to three carbohydrate gel packs per hour (25 g each). Subjects in both groups ran a mean of 69 km (range 48–80 km) in 9.8 h (range 5–12 h) and maintained an intensity of approximately 75% maximal heart rate (HRmax) throughout the ultramarathon race. Plasma ascorbic acid was higher in the vitamin C compared to placebo group pre-race, and increased significantly in the vitamin C group during the race [post-race, 3.21 (0.29) and 1.28 (0.12) µg/100 µl, respectively, P<0.001]. No significant group or interaction effects were measured for lipid hydroperoxide and F2-isoprostane, but both oxidative measures rose significantly during the ultramarathon race. Saliva volume, sIgA concentration, sIgA secretion and sIgA:saliva protein ratio all decreased significantly (P<0.001) during the race, but the pattern of change in all saliva measures did not differ significantly between groups. No significant correlations were found between post-race plasma vitamin C, oxidative, and saliva measures, except for a positive correlation between post-race serum cortisol and serum vitamin C (r=0.50, P=0.006). These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and sIgA changes during or following a competitive ultramarathon race.
Influence Of Vitamin C Supplementation On Oxidative And Salivary IgA Changes Following An Ultramarathon
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Created on 12/5/2019
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Additional Information
- Publication
- Palmer, F.M., Nieman, D.C., Henson, D.A. et al. (2003). Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon. Eur J Appl Physiol (2003) 89: 100-107. https:// doi.org/10.1007/s00421-002-0756-4. Publisher version of record available at: https://link.springer.com/article/10.1007/s00421-002-0756-4
- Language: English
- Date: 2003
- Keywords
- Exercise, Immune, Isoprostane, Lipid
hydroperoxide, Running