Experimental phenylketonuria in rats : an investigation of the critical interval hypothesis

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Paul Langdon Donahue (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/
David Cole

Abstract: The purpose of this experiment was to simulate PKU in rats and to determine if there were a critical period during which an increase of PA in the system has its most detrimental effect. Fifty-one Sprague-Dawley rats were paired at birth with a litter mate of the same sex and randomly assigned to one of three feeding conditions for administering the PA and control diets: beginning at birth (E-l, C-l), beginning at 18 days of age (E-2, C-2) and beginning at 36 days of age (E-3, C-3). Until weaning, E-l and C-l were fed by intubation. After weaning experimental animals were fed a 7% PA diet.

Additional Information

Language: English
Date: 1966

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