The effects of beta-endorphin on glucose homeostasis and hormonal responses during exercise

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Ioannis Georgiou Fatouros (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Allan H. Goldfarb

Abstract: Despite the fact that Beta-Endorphin (B-EP) has been shown to cause hyperglycemia at rest, it is not known if it influences glucose homeostasis and the glucoregulatory hormones during exercise. In an attempt to clarify the role of B-EP in glucose regulation and hormonal responses to prolonged dynamic exercise, 72 untrained, male Sprague-Dawley rats were assigned to one of three treatments: a) a control group infused with normal saline, b) a group infused with rat synthetic B-EP (0.05 mg*kg-l*h-l after a 0.05 mg/ kg bolus), and c) a group infused with naloxone (0.4 mg*kg-l *h-l after a 0.8 mg*kg-l bolus). All animals were familiarized with treadmill running for 4 days. On the fifth day they were catheterized in the jugular vein, and allowed 4 days recovery period. All recovered catheterized animals went through a second familiarization running period for 4 days. Finally, animals in each group were infused and killed either at 0 time or after 60, 90 and 120 minutes of running. Mixed venous samples were collected and subsequently analyzed for plasma glucose, lactate, insulin, C-peptide (C-P), glucagon, and B-EP.

Additional Information

Language: English
Date: 1994
Exercise $x Physiological aspects
Rats as laboratory animals

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