The relationship of select nutrients, obesity, cardiovascular fitness, and stress on the immune function of Reshape participants

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Rita Charlotte Sigmon (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:
Terry L. Bazzarre

Abstract: The purpose of this dissertation research was to evaluate the relative contribution of diet, obesity, cardiovascular fitness (CVF) and stress on three humoral components of the immune system: immunoglobulins (Ig3) IgA, IgG, IgM. Forty-seven obese subjects 17 to 89 years of age; 33.6% body fat (BF) were evaluated at weeks 0 (cross-sectional component) and 12 (longitudinal component) of the Reshape program (a 12- week intervention program which promotes lifestyle management (LM) through behavior modification of dietary intake, BF composition, CVF, and stress). Participants were screened for any medical conditions known to affect immune function. Anthropometries (% BF, body mass index (BMI), wai3t, hip circumferences), biochemical measures (IgA, IgG, IgM, hematocrit), four-day food records, CVF (mile walk time [MWT] and exercise heart rate [EHR]), and written stress evaluations (Current Self-Appraisal [CSA], State-Trait Anxiety.[STA]) were measured at weeks 0 and 12. Total energy intake (1926 ± 101 kcal) was 47% carbohydrate, 16% protein, and 36% fat, mean iron, zinc, copper, and beta-carotene intakes were below the RDA. Biochemical indices for IgA, IgG, IgM, and hematocrit were within normal ranges. In the cross-sectional study, IgM was negatively correlated with kcal (r=-0.32), protein (r=-0.32), fat (r=-0.32), iron (r=-0.33), and copper (r=-0.33) for the group; and with vitamin E for females (r=-0.48). Vitamins A, and C were positively correlated with IgA, while vitamin E was associated with IgM for males. Body weight and BMI were positively correlated with IgG, especially in females. BF was negatively correlated with IgM in females (r=-0.36). Both indices of CVF were positively correlated with IgM. Stress (CSA) was negatively correlated with IgA (r=-0.38).

Additional Information

Language: English
Date: 1992
Cardiovascular system
Immune system
Stress (Physiology)

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