Economic Impact Of A Rotavirus Vaccination Program In Mexico

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Richard Rheingans Ph.D., Department Chair (Creator)
Appalachian State University (ASU )
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Abstract: Objectives. To evaluate the cost and benefits of a national rotavirus childhood vaccination program in Mexico. Methods. A decision-analysis model was designed to take the Mexican health care system’s perspective on a comparison of two alternatives: to vaccinate against rotavirus or not. Using published, national data, estimations were calculated for the rotavirus illnesses, deaths, and disability-adjusted life years (DALYs) that would be averted and the incremental cost-effectiveness ratios (US$/DALY) of a hypothetical annual birth cohort of 2 285 000 children,with certain assumptions made for cost, coverage, and efficacy rates.Results. With 93% coverage and a vaccine price of US$ 16 per course (2 doses), a rotavirus vaccination program in Mexico would prevent an estimated 651 deaths (or 0.28 deaths per 1 000 children); 13 833 hospitalizations (6.05 hospitalizations per 1 000 children); and 414 927 outpatient visits (182 outpatient visits per 1 000 children) for rotavirus-related acute gastroenteritis (AGE). Vaccination is likely to reduce the economic burden of rotavirus AGE in Mexico by averting US$ 14 million (71% of the overall health care burden). At a vaccine price of US$ 16 per course, the cost-effectiveness ratio would be US$ 1 139 per DALY averted. A reduction in the price of the rotavirus vaccination program (US$ 8 per course) would yield alower incremental cost-effectiveness ratio of US$ 303 per DALY averted. Conclusions.A national rotavirus vaccination program in Mexico is projected to reducechildhood incidence and mortality and to be highly cost-effective based on the World HealthOrganization’s thresholds for cost-effective interventions.

Additional Information

Richard D. Rheingans, Dagna Constenla, F. Raúl Velázquez, Lynn Antil, and Yolanda Cervantes (2009) "Economic impact of a rotavirus vaccination program in Mexico" Rev Panam Salud Publica vol. 25 Iss.6 pp.481-490 Version of Record available from
Language: English
Date: 2009
Rotavirus, rotavirus vaccines, cost-benefit, analysis, mass immunization, gastroenteritis, Mexico

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