Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Matthew Burrell (Creator)

Michael Chernick (Creator)

Audrey Garrett (Creator)

Allan Hallquist (Creator)

Howard Homesley (Creator)

Manuel Penalver (Creator)

Mathieu Perree (Creator)

Cary A Presant (Creator)

James Rutledge (Creator)

Emery Salom (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Extracted text; Background This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. Methods A prospective, multi-institutional and blinded trial of the assay was conducted in 104 evaluable ovarian cancer patients treated with chemotherapy. The MiCK assay was performed prior to therapy, but treating physicians were not told of the results and selected treatment only on clinical criteria. Outcomes (response, time to relapse, and survival) were compared to the drug-induced apoptosis observed in the assay. Results Overall survival in primary therapy, chemotherapy naïve patients with Stage III or IV disease was longer if patients received a chemotherapy which was best in the MiCK assay, compared to shorter survival in patients who received a chemotherapy that was not the best. (p?

Additional Information

Publication

Other

Journal of Translational Medicine; 10: p. 162-162

Language: English

Date: 2012

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