Analysis of the mutation in cutaneous melanoma patients with occupational sun exposure

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

VALENTINA BEVELACQUA (Creator)

SAVERIO CANDIDO (Creator)

CONCETTINA FENGA (Creator)

PIETRO GANGEMI (Creator)

MASSIMO LIBRA (Creator)

ROBERTA MAESTRO (Creator)

GRAZIA MALAPONTE (Creator)

ANDREA MARCONI (Creator)

JAMES A. McCUBREY (Creator)

VENERANDO RAPISARDA (Creator)

AURORA SCALISI (Creator)

DEMETRIOS A. SPANDIDOS (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Extracted text; Sun-exposure is one of the risk factors associated with the development of a cutaneous neoplasm. In melanoma, the Ras-Raf-MEK-ERK (MAPK) signaling pathway is constitutively activated through multiple mechanisms, including B-RAF mutation. It has been hypothesized that B-RAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet (UV) radiation. However, it is still discussed if B-RAF mutations are associated with melanoma patients exposed to the sun. Therefore, in the present study, the known B-RAFV600E mutation was analysed in melanoma samples from 30 indoor and 38 outdoor workers. B-RAFV600E mutation was detected in 52 and 73% of outdoor workers and indoor workers, respectively. Of note, this mutation was identified in 12 of 14 (85%) melanoma of the trunk diagnosed in indoor workers and in 9 of 19 (47%) samples from outdoor workers (p=0.03). By analyzing melanomas of other body sites, no statistical difference in the frequency of B-RAFV600E mutation was identified between the groups of workers. It appears that the mutation detected among indoor workers may be associated with a recreational or intermittent exposure to the sun, as usually the trunk is a sun-protected body site. Overall, these data indicate that the B-RAFV600E mutation detected in melanoma is not associated with a chronic exposure to the sun. Mutations detected in other genes may also contribute to melanoma development in the subset of patients exposed to UV radiation.

Additional Information

Publication

Other

Oncology Reports; 31:3 p. 1079-1082

Language: English

Date: 2014

Keywords

B-RAFV600E mutations, melanoma, occupational sun exposure

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