Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Dr. . Murugi Ndirangu, Associate Professor (Creator)
Institution
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: Context—Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures. Objective—To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.Methods—In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.Results—Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.Conclusions—Different biomarkers of oxidative stress may reflect different biological processes.

Additional Information

Publication
Sindhu Lakkur, Roberd M. Bostick, Douglas Roblin, Murugi Ndirangu, Ike Okosun, Francis Annor, Suzanne Judd, W. Dana Flanders, Victoria L. Stevens, and Michael Goodman (2014) "Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants" Biomarkers 19(6): 471–480 Version of Record Available @ (doi:10.3109/1354750X.2014.937361)
Language: English
Date: 2014
Keywords
Oxidative balance, oxidative stress, race

Email this document to