Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon

ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
Andrew Shanely Ph.D, Associate Professor (Creator)
Kevin Zwetsloot Ph.D, Associate Professor (Creator)
Appalachian State University (ASU )
Web Site: https://library.appstate.edu/

Abstract: Adaptogens modulate intracellular signaling and increase expression of heat shock protein 72 (HSP72). Rhodiola rosea (RR) is a medicinal plant with demonstrated adaptogenic properties. The purpose of this study was to measure the in?uence of RR supplementation on exercise-induced muscle damage, delayed onset of muscle soreness (DOMS), plasma cytokines, and extracellular HSP72 (eHSP72) in experienced runners completing a marathon. Experienced marathon runners were randomized to RR (n = 24, 6 female, 18 male) or placebo (n = 24, 7 female, 17 male) groups and under double-blinded conditions ingested 600 mg/day RR extract or placebo for 30 days prior to, the day of, and seven days post-marathon. Blood samples were collected, and vertical jump and DOMS assessed the day before, 15 min post- and 1.5 h post-marathon. DOMS was also assessed for seven days post-marathon. Marathon race performance did not differ between RR and placebo groups (3.87 ± 0.12 h and 3.93 ± 0.12 h, respectively, p = 0.722). Vertical jump decreased post-marathon (time effect, p < 0.001) with no difference between groups (inter- action effect, p = 0.673). Post-marathon DOMS increased signi?cantly (p < 0.001) but the pattern of change did not differ between groups (p = 0.700). Myoglobin (Mb), creatine phosphokinase (CPK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin (IL)-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), granulocyte-colony-stimulating factor (G-CSF), C-reactive protein (CRP), and eHSP72 all increased post-marathon (all p < 0.001), with no group differences over time (all p > 0.300). In conclusion, RR supplementation (600 mg/day) for 30 days before running a marathon did not attenuate the post-marathon decrease in muscle function, or increases in muscle damage, DOMS, eHSP72, or plasma cytokines in experienced runners.

Additional Information

R. Andrew Shanely, David C. Nieman, Kevin A. Zwetsloot, Amy M. Knab, Hidetaka Imagita, Barbara Davis, José M. Zubeldia(2014) "Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and in?ammation in runners following a competitive marathon" Brain, Behavior & immunity 39 204-210. Version of record available @ (doi: 10.1016/j.bbi.2013.09.005)
Language: English
Date: 2014
, adaptogen, cytokine, heat-shock-protein-72, Skeletal muscle damage,

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