Changes in serum collagen markers, IGF-I, and Knee joint laxity across the menstrual cycle

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Sandra J. Shultz, Professor and Chair (Creator)
Laurie Wideman, Safrit-Ennis Distinguished Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
Web Site:

Abstract: Variations in serum markers of collagen production (CICP) and degradation (ICTP), insulin-like growth factor I (IGF-I) and anterior knee laxity (AKL) were measured in 20 women [10 with spontaneous cycles (eumenorrheic), 10 using oral contraceptives] over 5 consecutive days at menses (M1–M5, 1st pill week), the initial estrogen rise near ovulation (O1–O5, 2nd pill week), the initial progesterone rise of the early luteal phase (EL1–EL5, 3rd pill week) and post-progesterone peak of the late luteal phase (LL1–LL5, 4th pill week). ICTP was higher in oral contraceptive women (5.3±1.7 vs. 3.7±1.3µg/L; p=0.030), primarily during days near ovulation and the early luteal phase when concentrations decreased in eumenorrheic women (p=0.04). IGF-I concentrations increased during menses then decreased and remained lower during the early and late luteal phase in oral contraceptive women, resulting in lower concentrations compared to eumenorrheic women at EL2 and LL1 (p=0.03). CICP decreased in early and late luteal days (p<0.01), and there was a trend toward lower concentrations in eumenorrheic versus oral contraceptive women (85.7±35.7ng/ml vs. 123.2±49.8ng/ml; p=0.07). Lower CICP and greater IGF-I concentrations predicted greater AKL across the 20 cycle days in both groups (R2=0.310 and 0.400). Sex hormone concentration changes across the menstrual cycle are of sufficient magnitude to influence collagen metabolism, and may indirectly influence knee structure and function.

Additional Information

Journal of Orthopaedic Research. 2012; 30(9):1405–1412
Language: English
Date: 2012
collagen markers, growth factors, menstrual cycle, sex hormones, knee laxity, ACL

Email this document to