HPLC Determination of Amphetamine and Guanfacine

UNCP Author/Contributor (non-UNCP co-authors, if there are any, appear on document)
Kendra Dorn (Creator)
The University of North Carolina at Pembroke (UNCP )
Web Site: http://www.uncp.edu/academics/library
Dr. Meredith Storms

Abstract: Stimulant medications are most often prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and fetal alcohol syndrome (FAS). However, about 20% of the children taking stimulants do not have much symptom relief or they suffer from side effects. As a result, adjunctive therapy is often recommended. One approach is to prescribe Intuniv® (guanfacine) with an ADHD stimulant medication such as Adderall® (amphetamine). Many research studies report that Intuniv® given in combination with a stimulant leads to significant improvements in ADHD and impulsivity symptoms. Therefore, the purpose of this research is to develop an HPLC method to simultaneously determine the concentration of amphetamine and guanfacine in dosage form, which could then be used in the analysis of biological fluids.

Additional Information

Honors Project
Esther G. Maynor Honors College
Language: English
Date: 2015
Attention Deficit Hyperactivity Disorder (ADHD), Fetal Alcohol Syndrome (FAS), Stimulant Medications, Guanfacine, Amphetamine, High Performance Liquid Chromatography (HPLC) Method, Biological Samples

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