Review of microdialysis in brain tumors from concept to application: First Annual Carolyn Frye-Halloran Symposium

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Ramsis K. Benjamin (Creator)

Peter M. Bungay (Creator)

Idil Cavus (Creator)

Jerry M. Collins (Creator)

O. Michael Colvin (Creator)

Groot John F. de (Creator)

William F. Elmquist (Creator)

Elizabeth Fox (Creator)

James M. Gallo (Creator)

Stuart A. Grossman (Creator)

Robert C. Hickner (Creator)

Fred H. Hochberg (Creator)

Robert P. Pelletier (Creator)

Clinton F. Stewart (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: In individuals with brain tumors pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid which unfortunately do not necessarily reflect concentrations within the tumor and adjacent brain. This review article introduces to neurological and medical oncologists as well as pharmacologists the application of microdialysis in monitoring drug metabolism and delivery within the fluid of the interstitial space of brain tumor and its surroundings. Microdialysis samples soluble molecules from the extracellular fluid via a semipermeable membrane at the tip of a probe. In the past decade it has been used predominantly in neurointensive care in the setting of brain trauma vasospasm epilepsy and intracerebral hemorrhage. At the first Carolyn Frye-Halloran Symposium held at Massachusetts General Hospital in March 2002 the concept of microdialysis was extended to specifically address its possible use in treating brain tumor patients. In doing so we provide a rationale for the use of this technology by a National Cancer Institute consortium New Approaches to Brain Tumor Therapy to measure levels of drugs in brain tissue as part of phase 1 trials. Originally published Neuro-oncology Vol. 6 No. 1 Jan 2004

Additional Information

Publication

Other

Neuro-Oncology. 6:1(January 2004) p. 65-74.

Language: English

Date: 2011

Keywords

brain tumors, microdialysis, drug metabolism, drug delivery

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