Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Elizabeth N. Allred (Creator)

Haim Bassan (Creator)

Daniel Batton (Creator)

Olaf Dammann (Creator)

Steve Engelke (Creator)

Joseph Junewick (Creator)

Padmani Karna (Creator)

Cecelia E. Keller (Creator)

Kalpathy Krishnamoorthy (Creator)

Karl C. K. Kuban (Creator)

Alan Leviton (Creator)

Cindy R. Miller (Creator)

Sunila E. O'Connor (Creator)

T. Michael O'Shea (Creator)

Nicholas Olomu (Creator)

Marcello Pagano (Creator)

Nigel Paneth (Creator)

Adre Du Plessis (Creator)

Elaine Romano (Creator)

Joanna Seibert (Creator)

Sjirk J. Westra (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage ventriculomegaly and echolucency by multiple sonologists. Standardized neurological examinations classified cerebral palsy and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality. Originally published Journal of Child Neurology Vol. 24 No. 1 Jan 2009

Additional Information

Publication

Other

Journal of Child Neurology. 24:1(January 2009) p. 63-72.

Language: English

Date: 2011

Keywords

cerebral palsy, estremely low gestational age, cranial ultrasound

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