Qun Lu

There are 8 included publications by Qun Lu :

TitleDateViewsBrief Description
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants 2011 5883 Many chemotherapy drugs are known to cause significant clinical neurotoxicity which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to understand the toxicity of these dr...
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation 2011 5883 delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However the molecular mechanisms by which delta-catenin promotes dendritic morphogenesis w...
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles 2011 5883 Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However delta-catenin is upregulated in human prostatic adenocarcinomas although the effects of...
E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin 2011 5883 δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here we describe istinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial ells. In HEK293 cells maintained in low cell densitie...
Identification of E2F1 as a positive transcriptional regulator for delta-catenin 2011 5883 Delta-Catenin is upregulated in human carcinomas. However little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system we have screened several nuclear signa...
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer 2011 5883 Cancer pathogenesis involves multiple genetic and epigenetic alterations which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are highly variable. Here we rep...
Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover 2011 5883 Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1) the effects of PS-1 on delta-catenin have not been established. In this study we report that overexpression of PS-1 inhibits...
Small Molecule Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment 2011 5883 The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested he hypothesis that non-peptide small molecule p75NTR ligands found to promote survival signaling might prevent Abinduced e...