Caroline Smith

Education Postdoctoral Research Fellow, The Pennsylvania State University (2010-2013) Specialization: Thermal and microvascular physiology Ph.D. Loughborough University, UK (2005-2009) Specialization; Thermal Physiology B.Sc. (Hons) Human Biology, Loughborough University, UK (2002-2005) Current Teaching ES 3005: Physiological Assessment ES 2032: Anatomy & Physiology II Professional Affiliations American Physiological Society American College of Sports Medicine Research Interests Examining in vivo and in vitro signaling mechanisms underlying thermoregulatory and microvascular dysfunction in diabetic and cardiovascular disease populations, and the impact of exercise and thermal interventions on vascular responses. Current research studies include examining changes in eccrine sweating and vascular function with heat therapy in hyperglycemic and diabetic patients, and elucidating the mechanisms by which metformin improves vascular function in type II diabetes mellitus.

There are 7 included publications by Caroline Smith :

TitleDateViewsBrief Description
Blood Pressure Normalization Via Pharmacotherapy Improves Cutaneous Microvascular Function Through NO-Dependent And NO-Independent Mechanisms 2017 63 Hypertension is associated with endothelial dysfunction and vascular remodeling. Objective: To assess effects of antihypertensive pharmacotherapy on eNOS-and iNOS-dependent mechanisms and maximal vasodilator capacity in the cutaneous microvasculature...
Design Data For Footwear: Sweating Distribution On The Human Foot 2013 280 Purpose – The purpose of this paper is to provide footwear designers, manikin builders and thermo-physiological modellers with sweat distribution information for the human foot. Design/methodology/approach – Independent research from two laboratories...
Effects Of Resistance Exercise Timing On Sleep Architecture And Nocturnal Blood Pressure 2015 73 Short sleep duration and poor quality of sleep have been associated with health risks including cardiovascular disease, diabetes, and obesity. Prior research has suggested that regular aerobic exercise improves the quality of sleep; however, less is ...
Non-Uniform, Age-Related Decrements In Regional Sweating And Skin Blood Flow 2013 156 Aging is associated with attenuated thermoregulatory function that varies regionally over the body. Decrements in vasodilation and sweating are well documented with age, yet limited data are available concerning the regional relation between these re...
Regional Relation Between Skin Blood Flow And Sweating To Passive Heating And Local Administration Of Acetylcholine In Young, Healthy Humans 2013 117 Regional variation in sweating over the human body is widely recognized yet variation in vasomotor responses and mechanisms causing this variation remain unclear. This study aimed to explore the relation between regional sweating rates (RSR) and skin...
Responses To Hyperthermia. Optimizing Heat Dissipation By Convection And Evaporation: Neural Control Of Skin Blood Flow And Sweating In Humans 2016 294 Under normothermic, resting conditions, humans dissipate heat from the body at a rate approximately equal to heat production. Small discrepancies between heat production and heat elimination would, over time, lead to significant changes in heat stora...
Rho-Kinase Activity And Cutaneous Vasoconstriction Is Upregulated In Essential Hypertensive Humans 2013 148 Essential hypertension (HT) is associated with endothelial dysfunction augmented vasoconstriction (VC) which may be secondary to increased Rho/Rho-Kinase (ROCK)-dependent mechanisms. Our aim was to assess the in vivo magnitude of cutaneous VC to loca...