Michael Fernandes de Almeida
- Research Specialist
- Biotechnology Research and Training Center, UNCP
- biotech@uncp.edu
- 910-521-6650
- Office for Regional Initiatives
- Pembroke NC 28372
There are 4 included publications by Michael Fernandes de Almeida :
| Title | Date | Views | Brief Description |
|---|
| Aß42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways |
2017 |
486 |
Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer’s disease (AD). Protein degradation through the proteasome pathway decreases with age and in AD brains, and the Aß42 peptide has been shown to ... |
| Effects of mild running on substantia nigra during early neurodegeneration |
2017 |
1270 |
Moderate physical exercise acts at molecular and behavioural levels, such as interfering in neuroplasticity, cell death, neurogenesis, cognition and motor functions. Therefore, the aim of this study is to analyse the cellular effects of moderate trea... |
| Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon |
2017 |
1595 |
The anticholinesterase paraoxon (Pxn) is related to military nerve agents that increase acetylcholine levels, trigger seizures, and cause excitotoxic damage in the brain. In rat hippocampal slice cultures, high-dose Pxn was applied resulting in a pre... |
| Plant Extracts Stimulate the Autophagy-Lysosomal Protein Clearance Pathway and Improve Brain Synapse Markers in an Explant Model of Age-Related Protein Accumulation Stress |
2019 |
162 |
Brain aging causes gradual protein accumulation pathology as clearance systems depreciate, leading to synaptic compromise, cognitive decline, and contributing as the primary risk factor of dementia. Removal of old and damaged proteins becomes less ef... |