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Michael K. McIntosh

**Education:- Ph.D., University of Georgia, 1987 - M.S., University of Alberta, 1983 - B.S., Ohio University, 1973 **Research Interests: *Obesity and Type 2 Diabetes: - How does increased adiposity promote inflammation and insulin resistance? - What role do (pre)adipocytes, macrophages, and myotubes play in mediating inflammation and insulin resistance associated with obesity? *Nutritional Regulation of Human Adipocytes and Cross-talk with Macrophages: - How do saturated or trans fatty acids impact adipocyte gene/protein expression and metabolism, signaling, and insulin sensitivity? - Mechanism(s) by which grape powder extract, mangosteen, or their bioactive components prevent inflammation and insulin resistance?

There are 3 included publications by Michael K. McIntosh :

TitleDateViewsBrief Description
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation AUTOCRINE/PARACRINE REGULATION OF MEK/ERK SIGNALING BY ADIPOCYTOKINES 2004 113 Dietary conjugated linoleic acid (CLA) reduces body fat in animals and some humans. Here we show that trans-10, cis-12 CLA, but not cis-9, trans-11 CLA, when added to cultures of stromal vascular cells containing newly differentiated human adipocytes...
Conjugated Linoleic Acid Promotes Human Adipocyte Insulin Resistance through NF?B-dependent Cytokine Production 2005 142 We previously demonstrated that trans-10, cis-12 conjugated linoleic acid (CLA) reduced the triglyceride content of human adipocytes by activating mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK) signaling via int...
Isomer-Specific Regulation of Metabolism and PPARy Signaling by CLA in Human Preadipocytes 2003 179 Trans-10,cis-12 conjugated linoleic acid (CLA) has previously been shown to be the CLA isomer responsible for CLA-induced reductions in body fat in animal models, and we have shown that this isomer, but not the cis-9,trans-11 CLA isomer, specifically...