The Antibacterial Efficacy Of Ethanolic Whole-Leaf Moringa Oleifera Sub-Fractions On Escherichia Coli
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Tanner Marc Orders (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
- Advisor
- Chishimba Nathan Mowa
Abstract: In an effort to provide safer alternative options to pharmaceutical-based antibacterial treatment for infection-induced preterm labor, we have previously used whole-leaf extracts and high performance liquid chromatography (HPLC)-isolated subfractions of hydroethanolic Moringa oleifera (MO) to screen the antibacterial efficacy of MO against Escherichia coli (E. coli), a leading cause of urinary tract infections associated with preterm labor. These earlier studies found the ethanolic whole-leaf extract as well as three subfractions out of eight, to be the most potent. Here, we test the potency of each sub-fraction as well as investigate whether the antibacterial effects of the most potent leaf sub-fractions act synergistically, using in vitro liquid broth assays in a dose-dependent manner. Of the eight sub-fraction screened, sub-fraction five exerted the most antibacterial efficacy against E. coli. No significant synergistic antibacterial activity was observed between subfractions four, five, and six. We conclude that the anti-bacterial activity of whole leaf M. oleifera is exerted by the potent subfractions in a non-synergistic manner. Ongoing studies in our lab are testing the antibacterial potential of MO whole seed extracts.
The Antibacterial Efficacy Of Ethanolic Whole-Leaf Moringa Oleifera Sub-Fractions On Escherichia Coli
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Created on 6/21/2018
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Additional Information
- Publication
- Honors Project
- Orders, T. (2018). "The Antibacterial Efficacy Of Ethanolic Whole-Leaf Moringa Oleifera Sub-Fractions On Escherichia Coli." Unpublished Honors Thesis. Appalachian State University, Boone, NC.
- Language: English
- Date: 2018
- Keywords
- Moringa Oleifera, Escherichia Coli, Antibacterial, Phytochemicals, Pre-Term Birth