Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise
- ASU Author/Contributor (non-ASU co-authors, if there are any, appear on document)
- Chelsea Dawn Curry (Creator)
- Anne Marie Moody (Creator)
- Institution
- Appalachian State University (ASU )
- Web Site: https://library.appstate.edu/
Abstract: Obesity-related hypertension is associated with increased activity of the renin-angiotensin-aldosterone system (RAAS), increasing arterial stiffness. Aerobic exercise decreases pulse wave velocity (PWV), therefore a treatment option for hypertension and obesity. Assess RAAS activity and PWV before and after 4 weeks of aerobic training in unmedicated, pre-to-stage-1 hypertensives. Ten obese subjects (52±3.2 years, body mass index ¼ 33.5±1.4) performed 30 min of aerobic exercise on a treadmill 3 days per week at 65%of peak oxygen consumption (VO2peak). Descriptive characteristics, systolic and diastolic blood pressure (SBP and DBP), PWV, and a blood draw was performed at baseline, following the 4-week control and training interventions. No differences in descriptive characteristics during the control period were observed, however, a signi?cant decrease in plasma aldosterone (ALDO) (255.4±75 to 215.8±66 pg ml 1, P ¼ 0.001), SBP (140±12 to 136±10.4 mm Hg; P ¼ 0.02), DBP (89±4.2 to 85±6.3 mm Hg; P ¼ 0.03) and central PWV (11.2±0.6 to 9.8±0.8 m s 1; P ¼ 0.04) was shown pre-to-post exercise training. Four weeks of moderate-intensity aerobic training in obese, hypertensives decreases plasma ALDO independently of body weight and is signi?cantly correlated to decreases in PWV reductions.
Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise
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Created on 10/18/2016
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Additional Information
- Publication
- AM Moody, SR Collier, CD Curry, K Sandberg, V Frechette, H Ji, R Gowdar, D Chaudhuri and M Meucci (2015) "Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise" Journal of Human Hypertenstion Volume 29 issue 1 pp.53-57 [doi:10.1038/jhh.2014.33] Version of Record Available from (www.nature.com/jhh)
- Language: English
- Date: 2015
- Keywords
- aerobic exercise, plasma aldosterone, ALDO