The relationship between oxidized low-density lipoprotein and paraoxonase 1 following acute exercise
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Charles Elliot Robison (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Paul Davis
Abstract: Heart disease and stroke cause significant death and disability in industrialized nations. Oxidized low-density lipoprotein (ox-LDL) is an essential component of the plaque formation within arteries that leads to these conditions. Paraoxonase 1 (PON1) is an antioxidant enzyme capable of preventing the oxidation of LDL. The purpose of this study was to measure the relationship between ox-LDL concentration and PON1 activity in response to acute exercise. Fifteen aerobically trained individuals (M=12, F=3, VO2 max= 54.8 ± 1.7 mlkg-1min-1, BMI = 22.9± 0.5kgm-2) completed separate exercise treatment sessions at 60% and 80% VO2 max for 30 minutes. Ox-LDL concentration and PON1 activity were measured immediately before (PRE), immediately post (0 POST), and 15 minutes post (15 POST) exercise. To ascertain the degree of oxidative stress induced by the exercise sessions, protein carbonyl (PC) concentration and total antioxidant capacity (TAC) were measured at PRE and 0 POST. Repeated measures analyses of variance revealed that ox-LDL concentration and PON1 activity failed to change significantly in response to both the 60% and 80% treatment sessions. In addition, Pearson product moment correlations found no significant relationships between the changes in ox-LDL and PON1 at any time point (p>0.05). There were no significant changes in PC or TAC from PRE to 0 POST in either treatment. The results from this study indicate that thirty minutes of running at 80% VO2max was not sufficient to induce oxidative stress and elevate ox-LDL concentrations and PON1 activity in these highly trained subjects.
The relationship between oxidized low-density lipoprotein and paraoxonase 1 following acute exercise
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Created on 12/1/2011
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Additional Information
- Publication
- Dissertation
- Language: English
- Date: 2011
- Keywords
- Cardiovascular, Exercise, Oxidized LDL, Paraoxonase 1
- Subjects
- Exercise $x Physiological aspects $x Research
- Cardiovascular fitness $x Physiological aspects $x Research
- Low density lipoproteins $x Physiological effect
- Paraoxonase $x Physiological effect