Effects of d-Amphetamine and Scopolamine on Activity Before and After Shock in Three Mouse Strains
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Douglas Wahlsten, Visiting Professor (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
Abstract: In three experiments the following results were obtained: (a) Activity was greater both prior to and following exposure to shock among C57BL/6J mice than in DBA/2J mice, which in turn was greater than that of A/J mice. (b) Scopolamine hydrobromide increased general activity in DBA/2 and A mice, but had either no effect or decreased activity in the C57BL/6 strain. Following exposure to shock, however, the disinhibitory effects of scopolamine were apparent in all three strains. (c) d-amphetamine increased activity in all three strains. Moreover, following a single shock d-amphetamine had excitatory effects among both A and DBA/2 mice such that activity exceeded the level observed with d-amphetamine alone. Following several shock presentations a small but significant excitation was observed in C57BL/6 mice as well. Data were interpreted in terms of disinhibitory and excitatory effects of scopolamine and d-amphetamine, respectively, as well as possible interactions between the catecholaminergic and cholinergic systems. In addition, implications for sources of strain differences in avoidance behavior are discussed.
Effects of d-Amphetamine and Scopolamine on Activity Before and After Shock in Three Mouse Strains
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Created on 4/14/2011
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Additional Information
- Publication
- Pharmacology, Biochemistry and Behavior, 1975, 3, 819-824.
- Language: English
- Date: 1975
- Keywords
- Activity, Behavior genetics, Inbred strain, d-Amphetamine, Scopolamine, Stress